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Article

Canine multi-drug resistance-1 mutation prevalence: A South African perspective.

Journal of the South African Veterinary Association - 14 Nov 2014

le Roux-Pullen Lérica, van der Zwan Henriëtte

Abstract excerpt

The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between...

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PMID: 25686216
DOI: 10.4102/jsava.v85i1.1139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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