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Article

Breed is associated with the ABCB1-1Δ mutation in Australian dogs.

Australian veterinary journal - 1 Mar 2020

Soussa R W, Woodward A, Marty M, Cannon C M

Abstract excerpt

OBJECTIVE: The ABCB1 gene encodes P-glycoprotein (P-gp), a cellular membrane pump. One functional mutation that leads to expression of a less functional form of P-gp, ABCB1-1Δ, has been described in dogs. Individuals with this mutation can have severe adverse reactions to common veterinary pharmaceuticals that are known substrates of this pump. We investigated the detection of this mutation in samples submitted...

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PMID: 31743433
DOI: 10.1111/avj.12896

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