Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Review of prevalence, genetic aspects and adverse effects of the mdr1-1Delta mutation in dogs.

DTW. Deutsche tierarztliche Wochenschrift - 1 Jun 2008

Fecht S, Distl O

Abstract excerpt

A mutation in the canine MDR1 gene causes multiple drug sensitivity in dog breeds of the Collie lineage. Dogs with this genetic defect show severe neurotoxic adverse effects if they are treated with particular drugs. Clinical signs depending on the administered drug and its concentration vary from mild toxicosis with salivation and disorientation to severe effects with coma and finally death of the dog. Drugs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Breeding
Share to Dog Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MDR

Share to Genotype

Share to Neurotoxicity Syndromes

Share to Prevalence

Source

Identifiers

PMID: 18605373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Review of prevalence, genetic aspects and adverse effects of the mdr1-1Delta mutation in dogs.PMID 18605373Read ↗

Breed distribution of the nt230(del4) MDR1 mutation in dogs.Semantic proximity Read ↗

SNP genetic polymorphisms of MDR-1, CYP1A2 and CYPB11 genes in four canine breeds upon toxicological evaluation.Semantic proximity Read ↗

The prevalence of ABCB1:c.227_230delATAG mutation in affected dog breeds from European countries.Semantic proximity Read ↗

Canine multi-drug resistance-1 mutation prevalence: A South African perspective.Semantic proximity Read ↗

Therapeutic implications of the MDR‐1 geneSemantic proximity Read ↗

Frequency of canine nt230(del4) MDR1 mutation in prone pure breeds, their crosses and mongrels in Israel - insights from a worldwide comparative perspective.Semantic proximity Read ↗

The canine blood-brain barrier in health and disease: focus on brain protectionSemantic proximity Read ↗

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany.Semantic proximity Read ↗

MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.Semantic proximity Read ↗

Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies.Semantic proximity Read ↗

Analysis of the canine mdr1-1Delta mutation in the dog breed Elo.Semantic proximity Read ↗

Canine and feline P‐glycoprotein deficiency: What we know and where we need to goSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.