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Development of a PCR‐based diagnostic test detecting a nt230(del4) MDR1 mutation in dogs: verification in a moxidectin‐sensitive Australian Shepherd

1 Feb 2005

Abstract excerpt

A subpopulation of dogs of the Collie and Australian Shepherd breeds show increased sensitivity to central nervous actions of ivermectin, doramectin, loperamide, and probably several other drugs. The molecular background for this greater sensitivity is a nonsense mutation in the MDR1 efflux pump, which is part of the functional blood-brain barrier and normally limits drug penetration into the brain. This report...

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PMID: 15720521
DOI: 10.1111/j.1365-2885.2004.00625.x

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