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Article

Therapeutic implications of the MDR‐1 gene

1 Oct 2004

Abstract excerpt

Drug transporters significantly influence drug pharmacokinetics and pharmacodynamics. P-glycoprotein (P-gp), the product of the MDR1 (ABCB1) gene, is among the most well-characterized drug transporters, particularly in veterinary medicine. A number of clinically relevant, structurally and functionally unrelated drugs are substrates for P-gp. P-gp is expressed by a variety of normal tissues including the...

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PMID: 15500562
DOI: 10.1111/j.1365-2885.2004.00607.x

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