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Article

Clinicopathological, molecular, and prognostic features of colorectal carcinomas with KRAS c.34G>T (p.G12C) mutation.

Cancer science - 1 Oct 2024

Ugai Satoko, Yao Qian, Takashima Yasutoshi, Zhong Yuxue, Matsuda Kosuke, Kawamura Hidetaka, Imamura Yu, Okadome Kazuo, Mima Kosuke, Arima Kota, Kosumi Keisuke, Song Mingyang, Meyerhardt Jeffrey A, Giannakis Marios, Nowak Jonathan A, Ugai Tomotaka, Ogino Shuji

Abstract excerpt

Evidence indicates that combinations of anti-EGFR antibodies and KRAS p.G12C (c.34G>T) inhibitors can be an effective treatment strategy for advanced colorectal cancer. We hypothesized that KRAS c.34G>T (p.G12C)-mutated colorectal carcinoma might be a distinct tumor subtype. We utilized a prospective cohort incident tumor biobank (including 1347 colorectal carcinomas) and detected KRAS c.34G>T (p.G12C) mutation...

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PMID: 39039804
DOI: 10.1111/cas.16262
PMCID: PMC11448363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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