Article
Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry.
The Journal of molecular diagnostics : JMD - 1 Sept 2011
Beadling Carol, Heinrich Michael C, Warrick Andrea, Forbes Erin M, Nelson Dylan, Justusson Emily, Levine Judith, Neff Tanaya L, Patterson Janice, Presnell Ajia, McKinley Arin, Winter Laura J, Dewey Christie, Harlow Amy, Barney Oscar, Druker Brian J, Schuff Kathryn G, Corless Christopher L
Abstract excerpt
There is an immediate and critical need for a rapid, broad-based genotyping method that can evaluate multiple mutations simultaneously in clinical cancer specimens and identify patients most likely to benefit from targeted agents now in use or in late-stage clinical development. We have implemented a prospective genotyping approach to characterize the frequency and spectrum of mutations amenable to drug targeting...
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