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Article

New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma.

International journal of medical sciences - 1 Jan 2015

Dimitrov Lilia, Hong Christopher S, Yang Chunzhang, Zhuang Zhengping, Heiss John D

Abstract excerpt

In the last five years, IDH1 mutations in human malignancies have significantly shaped the diagnosis and management of cancer patients. Ongoing intense research efforts continue to alter our understanding of the role of the IDH1 mutation in tumor formation. Currently, evidence suggests the IDH1 mutation to be an early event in tumorigenesis with multiple downstream oncogenic consequences including maintenance of...

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Source

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Identifiers

PMID: 25678837
DOI: 10.7150/ijms.11047
PMCID: PMC4323358

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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