Article
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma.
Nature communications - 25 Oct 2023
Chen Xueqin, Liu Jun, Li Yuqin, Zeng Yuequan, Wang Fang, Cheng Zexiong, Duan Hao, Pan Guopeng, Yang Shangqi, Chen Yuling, Li Qing, Shen Xi, Li Ying, Qin Zixi, Chen Jiahong, Huang Youwei, Wang Xiangyu, Lu Yuli, Shu Minfeng, Zhang Yubo, Wang Guocai, Li Kai, Lin Xi, Xing Fan, Zhang Haipeng
Abstract excerpt
IDH1 mutations frequently occur early in human glioma. While IDH1 mutation has been shown to promote gliomagenesis via DNA and histone methylation, little is known regarding its regulation in antiviral immunity. Here, we discover that IDH1 mutation inhibits virus-induced interferon (IFN) antiviral responses in glioma cells. Mechanistically, D2HG produced by mutant IDH1 enhances the binding of DNMT1 to IRF3/7...
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