Article
IDH mutations in human glioma.
Neurosurgery clinics of North America - 1 Jul 2012
Kim Won, Liau Linda M
Abstract excerpt
A novel mutation of isocitrate dehydrogenase-1 (IDH1) was recently found in a large percentage of secondary human gliomas. Unlike previously discovered prognostic molecular characteristics, IDH1 mutations were found across gliomas of many different grades and histologies. Further studies have illuminated its utility as a prognostic marker in low-grade and high-grade gliomas and its ability to aid the...
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