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Article

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets.

British journal of cancer - 1 May 2020

Han Sue, Liu Yang, Cai Sabrina J, Qian Mingyu, Ding Jianyi, Larion Mioara, Gilbert Mark R, Yang Chunzhang

Abstract excerpt

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances in cancer genetics over the past decade have revealed that the genes encoding IDHs are frequently mutated in a variety of human malignancies, including gliomas, acute myeloid leukaemia, cholangiocarcinoma, chondrosarcoma and thyroid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32291392
DOI: 10.1038/s41416-020-0814-x
PMCID: PMC7250901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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