Article
Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: a multi-institution, multi-platform microarray study.
Cancer genetics - 1 Jan 2000
Baughn Linda B, Biegel Jaclyn A, South Sarah T, Smolarek Teresa A, Volkert Suzanne, Carroll Andrew J, Heerema Nyla A, Rabin Karen R, Zweidler-McKay Patrick A, Loh Mignon, Hirsch Betsy
Abstract excerpt
It is well documented that among subgroups of B-cell acute lymphoblastic leukemia (B-ALL), the genetic profile of the leukemic blasts has significant impact on prognosis and stratification for therapy. Recent studies have documented the power of microarrays to screen genome-wide for copy number aberrations (CNAs) and regions of copy number-neutral loss of heterozygosity (CNLOH) that are not detectable by...
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