Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

doi:10.1002/mgg3.70182

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Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Molecular genetics & genomic medicine - 1 Mar 2026

Mohd Dali Nor Soleha, Aziz Nursaedah Abdullah, Zulkifle Muhamad Farid, Zamri Durar Aqilah, Kamaluddin Nor Rizan, Yeoh Seoh-Leng, Ho Betty Lee-Sue, Din Nazzlin Dizana, Ab Ghani Azly Sumanty, Wan Hassan Wan Amal Hayati, Zakaria Zubaidah, Esa Ezalia, Mat Yusoff Yuslina

Abstract excerpt

INTRODUCTION: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a prevalent pediatric hematologic malignancy characterized by diverse chromosomal aberrations that significantly influence its prognosis. This study aimed to comprehensively characterize the genomic landscape of BCP-ALL in 55 Malaysian patients with BCP-ALL. METHODS: Single-nucleotide polymorphism (SNP) 6.0 microarray and multiplex...

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PMID: 41772825
DOI: 10.1002/mgg3.70182
PMCID: PMC12953716

Genes

CDKN2A
EBF1
ERG
ETV6
IKZF1
JAK2
PAX5

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