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Article

Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.

The Journal of general physiology - 1 Jan 2013

de Lange Willem J, Grimes Adrian C, Hegge Laura F, Ralphe J Carter

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) caused by mutations in cardiac myosin-binding protein-C (cMyBP-C) is a heterogenous disease in which the phenotypic presentation is influenced by genetic, environmental, and developmental factors. Though mouse models have been used extensively to study the contractile effects of cMyBP-C ablation, early postnatal hypertrophic and dilatory remodeling may overshadow primary...

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Identifiers

PMID: 23277475
DOI: 10.1085/jgp.201210837
PMCID: PMC3536521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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