Article
Reversibility of adverse, calcineurin-dependent cardiac remodeling.
Circulation research - 5 Aug 2011
Berry Jeff M, Le Vien, Rotter David, Battiprolu Pavan K, Grinsfelder Bennett, Tannous Paul, Burchfield Jana S, Czubryt Michael, Backs Johannes, Olson Eric N, Rothermel Beverly A, Hill Joseph A
Abstract excerpt
RATIONALE: Studies to dissect the role of calcineurin in pathological cardiac remodeling have relied heavily on murine models, in which genetic gain- and loss-of-function manipulations are initiated at or before birth. However, the great majority of clinical cardiac pathology occurs in adults. Yet nothing is known about the effects of calcineurin when its activation commences in adulthood. Furthermore, despite...
Topics
- Animals
- Calcineurin
- Cardiomegaly
- Disease Progression
- Doxycycline
- Female
- Fibrosis
- Gene Expression Regulation, Enzymologic
- Heart Failure
- Humans
- Male