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Article

IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients.

PloS one - 1 Jan 2015

Bordi Licia, Caglioti Claudia, Garbuglia Anna Rosa, Lapa Daniele, Castilletti Concetta, Taibi Chiara, Capobianchi Maria Rosaria, Lalle Eleonora

Abstract excerpt

Single-nucleotide polymorphism in IFNL3 gene (rs12979860) predicts spontaneous and therapy-induced HCV clearance. In a previous study from our group PBMC from patients with favourable rs12979860 genotype showed higher levels of IFNAR-1 mRNA. Recently, a dinucleotide polymorphism, ss469415590 (TT or ΔG), has been discovered in the region upstream IFNL3 gene, which is in high linkage disequilibrium with rs12979860....

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Share to Hepatitis C
Share to Hepatitis C, Chronic
Share to Interferon-alpha
Share to Interferons
Share to Interleukins
Share to Leukocytes, Mononuclear
Share to Receptor, Interferon alpha-beta
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Source

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Identifiers

PMID: 25675103
DOI: 10.1371/journal.pone.0117397
PMCID: PMC4326132

Genes

IFNL3

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