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Article

Replication fork integrity and intra-S phase checkpoint suppress gene amplification.

Nucleic acids research - 11 Mar 2015

Kondratova Anna, Watanabe Takaaki, Marotta Michael, Cannon Matthew, Segall Anca M, Serre David, Tanaka Hisashi

Abstract excerpt

Gene amplification is a phenotype-causing form of chromosome instability and is initiated by DNA double-strand breaks (DSBs). Cells with mutant p53 lose G1/S checkpoint and are permissive to gene amplification. In this study we show that mammalian cells become proficient for spontaneous gene amplification when the function of the DSB repair protein complex MRN (Mre11/Rad50/Nbs1) is impaired. Cells with impaired...

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Source

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Identifiers

PMID: 25672394
DOI: 10.1093/nar/gkv084
PMCID: PMC4357702

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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