Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma

6 Nov 2021

Abstract excerpt

Genetic aberrations are present in the ATRX gene in older high-risk neuroblastoma (NB) patients with very poor clinical outcomes. Its loss-of-function (LoF) facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells and is strongly linked to replication stress (RS) and DNA damage through G-quadruplex (G4) DNA secondary structures. However, limited information is available on ATRX...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glioma Diagnosis and Treatment
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34743173
DOI: 10.1038/s41389-021-00363-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastomaPMID 34743173Read ↗

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastomaSemantic proximity Read ↗

Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma CellsSemantic proximity Read ↗

The Chromatin Remodeler ATRX: Role and Mechanism in Biology and CancerSemantic proximity Read ↗

DNA repair and replicative stress addiction in neuroblastomaSemantic proximity Read ↗

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivitySemantic proximity Read ↗

<i>MYCN</i> Amplification and <i>ATRX</i> Mutations are Incompatible in NeuroblastomaSemantic proximity Read ↗

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres PathwaySemantic proximity Read ↗

Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics.Semantic proximity Read ↗

Targeting the DNA Damage Response for the Treatment of High Risk NeuroblastomaSemantic proximity Read ↗

ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cellsSemantic proximity Read ↗

MYCN amplification and ATRX mutations are incompatible in neuroblastoma.Semantic proximity Read ↗

ATRX, a guardian of chromatinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.