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Article

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.

Science (New York, N.Y.) - 22 Apr 2005

Lee Ji-Hoon, Paull Tanya T

Abstract excerpt

The ataxia-telangiectasia mutated (ATM) kinase signals the presence of DNA double-strand breaks in mammalian cells by phosphorylating proteins that initiate cell-cycle arrest, apoptosis, and DNA repair. We show that the Mre11-Rad50-Nbs1 (MRN) complex acts as a double-strand break sensor for ATM and recruits ATM to broken DNA molecules. Inactive ATM dimers were activated in vitro with DNA in the presence of MRN,...

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Source

Identifiers

PMID: 15790808
DOI: 10.1126/science.1108297

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.PMID 15790808Read ↗

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Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaksSemantic proximity Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restartSemantic proximity Read ↗

Early events in the mammalian response to DNA double-strand breaksSemantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and RepairSemantic proximity Read ↗

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Molecular basis of ataxia telangiectasia and related diseases.Semantic proximity Read ↗

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