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Article

Synergistic interaction between selective drugs in cell populations models.

PloS one - 1 Jan 2015

Doldán-Martelli Victoria, Míguez David G

Abstract excerpt

The design of selective drugs and combinatorial drug treatments are two of the main focuses in modern pharmacology. In this study we use a mathematical model of chimeric ligand-receptor interaction to show that the combination of selective drugs is synergistic in nature, providing a way to gain optimal selective potential at reduced doses compared to the same drugs when applied individually. We use a cell...

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Identifiers

PMID: 25671700
DOI: 10.1371/journal.pone.0117558
PMCID: PMC4324767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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