Modeling circadian clock-cell cycle interaction effects on cell population growth rates.

Abstract excerpt

The circadian clock and the cell cycle are two tightly coupled oscillators. Recent analytical studies have shown counter-intuitive effects of circadian gating of the cell cycle on growth rates of proliferating cells which cannot be explained by a molecular model or a population model alone. In this work, we present a combined molecular-population model that studies how coupling the circadian clock to the cell...

Topics

• ARNTL Transcription Factors
• Cell Cycle
• Cell Cycle Proteins
• Cell Proliferation
• Chronotherapy
• Circadian Clocks
• Cryptochromes
• Gene Expression Regulation
• Humans
• Models, Theoretical
• Mutation