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Cell facilitation promotes growth and survival under drug pressure in breast cancer

29 Jun 2023

Abstract excerpt

The interplay of positive and negative interactions between drug-sensitive and resistant cells influences the effectiveness of treatment in heterogeneous cancer cell populations. Here, we study interactions between estrogen receptor-positive breast cancer cell lineages that are sensitive and resistant to ribociclib-induced cyclin-dependent kinase 4 and 6 (CDK4/6) inhibition. In mono- and coculture, we find that...

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PMID: 37386030
DOI: 10.1038/s41467-023-39242-6

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