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Article

Cardiac specific expression of threonine 5 to alanine mutant sarcolipin results in structural remodeling and diastolic dysfunction.

PloS one - 1 Jan 2015

Shanmugam Mayilvahanan, Li Dan, Gao Shumin, Fefelova Nadezhda, Shah Vikas, Voit Antanina, Pachon Ronald, Yehia Ghassan, Xie Lai-Hua, Babu Gopal J

Abstract excerpt

The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of threonine 5 to alanine mutant SLN (SLNT5A). In these transgenic mice, the SLNT5A protein replaces the endogenous SLN in atria, while maintaining the total SLN...

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Source

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Identifiers

PMID: 25671318
DOI: 10.1371/journal.pone.0115822
PMCID: PMC4324845

Genes

SLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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