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Article

Activation of sarcolipin expression and altered calcium cycling in LMNA cardiomyopathy

18 May 2020

Abstract excerpt

Cardiomyopathy caused by A-type lamins gene (LMNA) mutations (LMNA cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. LMNA cardiomyopathy is highly penetrant with bad prognosis with no specific therapy available. Searching for alternative ways to halt the progression of LMNA cardiomyopathy, we studied the role of calcium homeostasis in the evolution of this disease. We...

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Cardiomyopathy and Myosin Studies
Nuclear Structure and Function
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32490213
DOI: 10.1016/j.bbrep.2020.100767

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