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Article

Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Gramolini Anthony O, Trivieri Maria G, Oudit Gavin Y, Kislinger Thomas, Li Wenping, Patel Mikin M, Emili Andrew, Kranias Evangelia G, Backx Peter H, Maclennan David H

Abstract excerpt

Sarcolipin (SLN) inhibits the cardiac sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) by direct binding and is superinhibitory if it binds as a binary complex with phospholamban (PLN). To demonstrate whether overexpression of SLN in the heart might impair cardiac function directly, transgenic (TG) mice with cardiac-specific overexpression of NF-SLN (SLN tagged at its N terminus with the FLAG epitope) were...

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Identifiers

PMID: 16461894
DOI: 10.1073/pnas.0510883103
PMCID: PMC1413737

Genes

SLN
PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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