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Article

Heterozygous deletion of sarcolipin maintains normal cardiac function.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2016

Shimura Daisuke, Kusakari Yoichiro, Sasano Tetsuo, Nakashima Yasuhiro, Nakai Gaku, Jiao Qibin, Jin Meihua, Yokota Tomohiro, Ishikawa Yoshihiro, Nakano Atsushi, Goda Nobuhito, Minamisawa Susumu

Abstract excerpt

Sarcolipin (SLN) is a small proteolipid and a regulator of sarco(endo)plasmic reticulum Ca(2+)-ATPase. In heart tissue, SLN is exclusively expressed in the atrium. Previously, we inserted Cre recombinase into the endogenous SLN locus by homologous recombination and succeeded in generating SLN-Cre knockin (Sln(Cre/+)) mice. This Sln(Cre/+) mouse can be used to generate an atrium-specific gene-targeting mutant, and...

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Identifiers

PMID: 26519028
DOI: 10.1152/ajpheart.00411.2015

Genes

SLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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