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Article

Ablation of sarcolipin results in atrial remodeling.

American journal of physiology. Cell physiology - 15 Jun 2012

Xie Lai-Hua, Shanmugam Mayilvahanan, Park Ji Yeon, Zhao Zhenghang, Wen Hairuo, Tian Bin, Periasamy Muthu, Babu Gopal J

Abstract excerpt

Sarcolipin (SLN) is a key regulator of sarco(endo)plasmic reticulum (SR) Ca(2+)-ATPase (SERCA), and its expression is altered in diseased atrial myocardium. To determine the precise role of SLN in atrial Ca(2+) homeostasis, we developed a SLN knockout (sln-/-) mouse model and demonstrated that ablation of SLN enhances atrial SERCA pump activity. The present study is designed to determine the long-term effects of...

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Identifiers

PMID: 22496245
DOI: 10.1152/ajpcell.00425.2011
PMCID: PMC3378074

Genes

SLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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