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Article

Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2005

Jia Li-Guo, Donnet Claudia, Bogaev Roberta C, Blatt Rebecca J, McKinney Cindy E, Day Kathleen H, Berr Stuart S, Jones Larry R, Moorman J Randall, Sweadner Kathleen J, Tucker Amy L

Abstract excerpt

Phospholemman (FXYD1), a 72-amino acid transmembrane protein abundantly expressed in the heart and skeletal muscle, is a major substrate for phosphorylation in the cardiomyocyte sarcolemma. Biochemical, cellular, and electrophysiological studies have suggested a number of possible roles for this protein, including ion channel modulator, taurine-release channel, Na(+)/Ca(2+) exchanger modulator, and...

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Source

Identifiers

PMID: 15563542
DOI: 10.1152/ajpheart.00142.2004

Genes

FXYD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice.PMID 15563542Read ↗

Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity.Semantic proximity Read ↗

Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman.Semantic proximity Read ↗

Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase.Semantic proximity Read ↗

Phosphorylation of phospholemman (FXYD1) by protein kinases A and C modulates distinct Na,K-ATPase isozymes.Semantic proximity Read ↗

Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.Semantic proximity Read ↗

Sarcoplasmic reticulum Ca-ATPase-phospholamban interactions and dilated cardiomyopathy.Semantic proximity Read ↗

Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart.Semantic proximity Read ↗

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The enhanced contractility of the phospholamban-deficient mouse heart persists with aging.Semantic proximity Read ↗

Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.Semantic proximity Read ↗

Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.Semantic proximity Read ↗

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