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Article

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient.

Journal of immunological methods - 1 Mar 2015

Freund Natalia T, Scheid Johannes F, Mouquet Hugo, Nussenzweig Michel C

Abstract excerpt

Isolation and characterization of anti HIV-1 broadly neutralizing antibodies (bNAbs) have elucidated new epitopes and sites of viral vulnerability. Anti-HIV-1 bNAbs typically show high levels of somatic mutations in their variable region genes. This feature potentially limits antibody identification, since the mutated antibody sequences are no longer complimentary to primers designed based on germline antibody...

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PMID: 25667013
DOI: 10.1016/j.jim.2015.01.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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