Article
Characterization of human IgG repertoires in an acute HIV-1 infection.
Experimental and molecular pathology - 1 Dec 2012
Chen Weizao, Prabakaran Ponraj, Zhu Zhongyu, Feng Yang, Streaker Emily D, Dimitrov Dimiter S
Abstract excerpt
All known broadly neutralizing antibodies (bnAbs) are highly somatically mutated and therefore significantly differ from their germline predecessors. Thus although the mature bnAbs bind to conserved epitopes of the HIV-1 envelope glycoprotein (Env) with high affinity their germline predecessors do not or weakly bind Envs failing to initiate an effective immune response. The identification of less somatically...
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