Article
Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2015
Scheepers Cathrine, Shrestha Ram K, Lambson Bronwen E, Jackson Katherine J L, Wright Imogen A, Naicker Dshanta, Goosen Mark, Berrie Leigh, Ismail Arshad, Garrett Nigel, Abdool Karim Quarraisha, Abdool Karim Salim S, Moore Penny L, Travers Simon A, Morris Lynn
Abstract excerpt
The human Ig repertoire is vast, producing billions of unique Abs from a limited number of germline Ig genes. The IgH V region (IGHV) is central to Ag binding and consists of 48 functional genes. In this study, we analyzed whether HIV-1-infected individuals who develop broadly neutralizing Abs show a distinctive germline IGHV profile. Using both 454 and Illumina technologies, we sequenced the IGHV repertoire of...
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