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Article

Statistical power and significance testing in large-scale genetic studies.

Nature reviews. Genetics - 1 May 2014

Sham Pak C, Purcell Shaun M

Abstract excerpt

Significance testing was developed as an objective method for summarizing statistical evidence for a hypothesis. It has been widely adopted in genetic studies, including genome-wide association studies and, more recently, exome sequencing studies. However, significance testing in both genome-wide and exome-wide studies must adopt stringent significance thresholds to allow multiple testing, and it is useful only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24739678
DOI: 10.1038/nrg3706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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