Article
Genome-wide association studies.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Iles Mark M
Abstract excerpt
Genome-wide association (GWA) studies are best understood as an extension of candidate gene association studies, scaled up to cover hundreds of thousands of markers across the genome in samples usually of several thousand cases and controls. The GWA approach allows the detection of much smaller effect sizes than with previous linkage-based genome-wide studies. However, this sensitivity makes them vulnerable to...
Topics
- Algorithms
- Genetics, Population
- Genome-Wide Association Study
- Genotype
- Humans
- Quality Control
- Reproducibility of Results
- Sample Size