The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants.

Abstract excerpt

Genome-wide association studies (GWAS) have long relied on proposed statistical significance thresholds to be able to differentiate true positives from false positives. Although the genome-wide significance P-value threshold of 5 × 10(-8) has become a standard for common-variant GWAS, it has not been updated to cope with the lower allele frequency spectrum used in many recent array-based GWAS studies and...

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• Alleles
• Diabetes Mellitus, Type 2
• Exome
• Genetic Heterogeneity
• Genome-Wide Association Study