Article
Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies.
European journal of human genetics : EJHG - 1 Jul 2010
Siontis Konstantinos C M, Patsopoulos Nikolaos A, Ioannidis John P A
Abstract excerpt
Genome-wide association studies (GWASs) have created a paradigm shift in discovering genetic associations for common diseases and phenotypes, but it is unclear whether the thousands of candidate genetic association studies performed in the pre-GWAS era had found any reliable associations for common diseases and phenotypes. We aimed to systematically evaluate whether loci proposed to harbor candidate associations...
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