Article

GWAS significance thresholds in large cohorts

2024-12-10

Abstract excerpt

While the p-value threshold of 5.0 × 10 −8 remains the standard for genome-wide association studies (GWAS) in humans and other species, it still needs to be updated to reflect the current era of large-scale GWAS, where tens of thousands of sample sizes are used to discover genetic associations at loci with smaller minor allele frequencies. In this study, we used a dataset of 348,501 individuals of European ancest...

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Literature Corpus work: 793d7e0b-e6a0-53d6-86f3-b43fc4edb707
DOI: 10.1101/2024.12.09.627629

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