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Article

Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.

Neuropharmacology - 1 Sept 2015

Shorey-Kendrick Lyndsey E, Ford Matthew M, Allen Daicia C, Kuryatov Alexander, Lindstrom Jon, Wilhelm Larry, Grant Kathleen A, Spindel Eliot R

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) are highly conserved between humans and non-human primates. Conservation exists at the level of genomic structure, protein structure and epigenetics. Overall homology of nAChRs at the protein level is 98% in macaques versus 89% in mice, which is highly relevant for evaluating subtype-specific ligands that have different affinities in humans versus rodents. In addition to...

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Identifiers

PMID: 25661700
DOI: 10.1016/j.neuropharm.2015.01.023
PMCID: PMC4486519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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