Article
Large-scale polymorphism discovery in macaque G-protein coupled receptors.
BMC genomics - 11 Oct 2013
Goswami Dharmendra B, Ogawa Lisa M, Ward Joshua M, Miller Gregory M, Vallender Eric J
Abstract excerpt
BACKGROUND: G-protein coupled receptors (GPCRs) play an inordinately large role in human health. Variation in the genes that encode these receptors is associated with numerous disorders across the entire spectrum of disease. GPCRs also represent the single largest class of drug targets and associated pharmacogenetic effects are modulated, in part, by polymorphisms. Recently, non-human primate models have been...
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