Article
The imprint of somatic hypermutation on the repertoire of human germline V genes.
Journal of molecular biology - 15 Mar 1996
Tomlinson I M, Walter G, Jones P T, Dear P H, Sonnhammer E L, Winter G
Abstract excerpt
In the human immune system, antibodies with high affinities for antigen are created in two stages. A diverse primary repertoire of antibody structures is produced by the combinatorial rearrangement of germline V gene segments and antibodies are selected from this repertoire by binding to the antigen. Their affinities are then improved by somatic hypermutation and further rounds of selection. We have dissected the...
Topics
- Antibody Diversity
- Binding Sites, Antibody
- Biological Evolution
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Variable Region
- Models, Genetic
- Models, Molecular
- Mutation