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Article

Role of Electrostatics in Protein-RNA Binding: The Global vs the Local Energy Landscape.

The journal of physical chemistry. B - 14 Sept 2017

Ghaemi Zhaleh, Guzman Irisbel, Gnutt David, Luthey-Schulten Zaida, Gruebele Martin

Abstract excerpt

U1A protein-stem loop 2 RNA association is a basic step in the assembly of the spliceosomal U1 small nuclear ribonucleoprotein. Long-range electrostatic interactions due to the positive charge of U1A are thought to provide high binding affinity for the negatively charged RNA. Short range interactions, such as hydrogen bonds and contacts between RNA bases and protein side chains, favor a specific binding site....

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Identifiers

PMID: 28806086
DOI: 10.1021/acs.jpcb.7b04318
PMCID: PMC6044910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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