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Article

Transcription driven somatic DNA methylation within the imprinted Gnas cluster.

PloS one - 1 Jan 2015

Mehta Stuti, Williamson Christine M, Ball Simon, Tibbit Charlotte, Beechey Colin, Fray Martin, Peters Jo

Abstract excerpt

Differential marking of genes in female and male gametes by DNA methylation is essential to genomic imprinting. In female gametes transcription traversing differentially methylated regions (DMRs) is a common requirement for de novo methylation at DMRs. At the imprinted Gnas cluster oocyte specific transcription of a protein-coding transcript, Nesp, is needed for methylation of two DMRs intragenic to Nesp, namely...

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Share to Chromogranins
Share to CpG Islands
Share to DNA, Intergenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Mice, Mutant Strains

Share to Multigene Family

Share to Transcription, Genetic

Source

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Identifiers

PMID: 25659103
DOI: 10.1371/journal.pone.0117378
PMCID: PMC4319783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Transcription driven somatic DNA methylation within the imprinted Gnas cluster.PMID 25659103Read ↗

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An imprinted transcript, antisense to <i>Nesp,</i> adds complexity to the cluster of imprinted genes at the mouse <i>Gnas</i> locusSemantic proximity Read ↗

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