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Article

A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.

Nature genetics - 1 Aug 2004

Williamson Christine M, Ball Simon T, Nottingham Wade T, Skinner Judith A, Plagge Antonius, Turner Martin D, Powles Nicola, Hough Tertius, Papworth David, Fraser William D, Maconochie Mark, Peters Jo

Abstract excerpt

Genomic imprinting brings about allele-specific silencing according to parental origin. Silencing is controlled by cis-acting regulatory regions that are differentially marked during gametogenesis and can act over hundreds of kilobases to silence many genes. Two candidate imprinting control regions (ICRs) have been identified at the compact imprinted Gnas cluster on distal mouse chromosome 2, one at exon 1A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Regulatory Sequences, Nucleic Acid

Source

Identifiers

PMID: 15273687
DOI: 10.1038/ng1398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.PMID 15273687Read ↗

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Identification of a Methylation Imprint Mark within the Mouse <i>Gnas</i> LocusSemantic proximity Read ↗

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