Article
Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.
Human molecular genetics - 1 Apr 2004
Li Tao, Vu Thanh H, Ulaner Gary A, Yang Youwen, Hu Ji-Fan, Hoffman Andrew R
Abstract excerpt
Activation and suppression of gene transcription is tightly controlled by epigenetic modifications. The imprinted Gnas1 gene region contains closely juxtaposed maternally expressed (Nesp) and paternally expressed (Nespas, Gnasxl, Exon 1A) transcripts, providing a unique opportunity to study how e...
Topics
- Alleles
- Animals
- Chromatin
- Chromogranins
- DNA Methylation
- Exons
- Female
- Fibroblasts
- GTP-Binding Protein alpha Subunits, Gs
- Gene Silencing
- Genomic Imprinting
- Histones
- Immunoprecipitation
- Male
- Mice
- Mice, Inbred C57BL
- Models, Genetic
- Polymerase Chain Reaction