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Article

Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.

Human molecular genetics - 1 Apr 2004

Li Tao, Vu Thanh H, Ulaner Gary A, Yang Youwen, Hu Ji-Fan, Hoffman Andrew R

Abstract excerpt

Activation and suppression of gene transcription is tightly controlled by epigenetic modifications. The imprinted Gnas1 gene region contains closely juxtaposed maternally expressed (Nesp) and paternally expressed (Nespas, Gnasxl, Exon 1A) transcripts, providing a unique opportunity to study how epigenetic modifications change in nucleosomes from active to silenced promoters. Using 30 polymorphic sites across the...

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PMID: 14962976
DOI: 10.1093/hmg/ddh081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.PMID 14962976Read ↗

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