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Article

Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.

PLoS genetics - 1 Mar 2011

Williamson Christine M, Ball Simon T, Dawson Claire, Mehta Stuti, Beechey Colin V, Fray Martin, Teboul Lydia, Dear T Neil, Kelsey Gavin, Peters Jo

Abstract excerpt

There is increasing evidence that non-coding macroRNAs are major elements for silencing imprinted genes, but their mechanism of action is poorly understood. Within the imprinted Gnas cluster on mouse chromosome 2, Nespas is a paternally expressed macroRNA that arises from an imprinting control region and runs antisense to Nesp, a paternally repressed protein coding transcript. Here we report a knock-in mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21455290
DOI: 10.1371/journal.pgen.1001347
PMCID: PMC3063750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.PMID 21455290Read ↗

Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.Semantic proximity Read ↗

A cis-acting control region is required exclusively for the tissue-specific imprinting of Gnas.Semantic proximity Read ↗

Control of imprinting at the Gnas cluster.Semantic proximity Read ↗

Transcription driven somatic DNA methylation within the imprinted Gnas cluster.Semantic proximity Read ↗

An imprinted transcript, antisense to <i>Nesp,</i> adds complexity to the cluster of imprinted genes at the mouse <i>Gnas</i> locusSemantic proximity Read ↗

A cluster of oppositely imprinted transcripts at the <i>Gnas</i> locus in the distal imprinting region of mouse chromosome 2Semantic proximity Read ↗

Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene.Semantic proximity Read ↗

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The imprinted oedematous-small mutation on mouse chromosome 2 identifies new roles for Gnas and Gnasxl in development.Semantic proximity Read ↗

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