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Article

Transcription is required for establishment of germline methylation marks at imprinted genes.

Genes & development - 1 Jan 2009

Chotalia Mita, Smallwood Sebastien A, Ruf Nico, Dawson Claire, Lucifero Diana, Frontera Marga, James Katherine, Dean Wendy, Kelsey Gavin

Abstract excerpt

Genomic imprinting requires the differential marking by DNA methylation of genes in male and female gametes. In the female germline, acquisition of methylation imprint marks depends upon the de novo methyltransferase Dnmt3a and its cofactor Dnmt3L, but the reasons why specific sequences are targets for Dnmt3a and Dnmt3L are still poorly understood. Here, we investigate the role of transcription in establishing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 19136628
DOI: 10.1101/gad.495809
PMCID: PMC2632167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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