Article
Restriction fragment length polymorphism of HLA and non-HLA genes in DR3/4 heterozygous Danish insulin-dependent diabetic patients and healthy individuals: reassessment of the influence of alpha DX and insulin-linked polymorphic loci, and new splits of DQw3 haplotypes.
Disease markers - 1 Jan 2000
Zerbib A, Mølvig J, Thomsen M, Coppin H, Cambon-Thomsen A, Sommer E, Nerup J, De Preval C
Abstract excerpt
We have investigated restriction fragment length polymorphism (RFLP) of HLA and non-HLA regions of the genome in the homogeneous Danish population. Insulin-dependent diabetes mellitus (IDDM) patients and healthy individuals were selected for being HLA-DR 3/4 heterozygous to evaluate the influence...
Topics
- Biomarkers
- DNA Probes
- Denmark
- Diabetes Mellitus, Type 1
- Genes, MHC Class I
- Genotype
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length