HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study.

doi:10.1007/BF00404640

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Article

HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study.

Diabetologia - 1 Jun 1990

Reijonen H, Ilonen J, Knip M, Michelsen B, Akerblom H K

Abstract excerpt

Finnish Type 1 (insulin-dependent) diabetic families were analysed for HLA-DQ beta-chain polymorphism using a short intron-specific probe. A simple hybridization pattern was obtained in which all fragments were associated significantly with Type 1 diabetes. The simultaneous presence of two different risk markers, the allelic 12-kilobase and 4-kilobase fragments were strongly associated with Type 1 diabetes since...

Topics

Adolescent
Alleles
B-Lymphocytes
Biomarkers
Child
Deoxyribonuclease BamHI
Diabetes Mellitus, Type 1
Finland
Genotype
HLA-DQ Antigens
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DR Antigens

Haplotypes

Humans

Polymorphism, Restriction Fragment Length

Reference Values

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 1974216
DOI: 10.1007/BF00404640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1974216-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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