Article
TcR-alpha and TcR-beta dialellic RFLPs in insulin-dependent (type I) Caucasian diabetic patients.
Diabetes research (Edinburgh, Scotland) - 1 Oct 1990
Boehm B O, Manfras B J, Rosak C, Kuehnl P, Schöffling K, Trucco M
Abstract excerpt
We studied the association of a T-cell receptor (TcR) beta restriction fragment length polymorphism (RFLP) and a new TcR-alpha RFLP with insulin-dependent (Type I) diabetes mellitus. This study is part of our effort to find new non-HLA disease genes involved in this chronic organ-specific autoimm...
Topics
- Alleles
- Base Sequence
- Deoxyribonuclease HindIII
- Diabetes Mellitus, Type 1
- Female
- Genetic Linkage
- Humans
- Macromolecular Substances
- Major Histocompatibility Complex
- Male
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Pedigree
- Polymorphism, Restriction Fragment Length
- Receptors, Antigen, T-Cell
- Reference Values
- White People