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Article

TcR-alpha and TcR-beta dialellic RFLPs in insulin-dependent (type I) Caucasian diabetic patients.

Diabetes research (Edinburgh, Scotland) - 1 Oct 1990

Boehm B O, Manfras B J, Rosak C, Kuehnl P, Schöffling K, Trucco M

Abstract excerpt

We studied the association of a T-cell receptor (TcR) beta restriction fragment length polymorphism (RFLP) and a new TcR-alpha RFLP with insulin-dependent (Type I) diabetes mellitus. This study is part of our effort to find new non-HLA disease genes involved in this chronic organ-specific autoimmune disease. Distribution of a 9.2 kb and a 10.0 kb diallelic TcR beta 2 RFLP was not different in diabetics and...

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PMID: 1983428

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