Article
An analysis of amplified insulin gene products in diabetics of Indian origin.
Journal of medical genetics - 1 Feb 1991
Hitman G A, Kambo P K, Viswanathan M, Mohan V
Abstract excerpt
We have previously described an increased incidence of the class 3 allele of the hypervariable region (HVR) 5' to the insulin gene in south Indian non-insulin dependent diabetics; this association is absent in Punjabi Sikhs with this disorder. Using the polymerase chain reaction we have amplified parts of the insulin gene from 130 subjects to look for mutations which may be in linkage disequilibrium with the...
Topics
- Alleles
- Base Sequence
- Chromosomes, Human, Pair 11
- Diabetes Mellitus, Type 2
- Gene Frequency
- Humans
- India
- Insulin
- Linkage Disequilibrium
- Molecular Sequence Data
- Polymerase Chain Reaction