Article
Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutation.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Feb 2021
Ren Rongqin, Krishna Somashekar G, Chen Wei, Frankel Wendy L, Shen Rulong, Zhao Weiqiang, Avenarius Matthew R, Garee Jason, Caruthers Sean, Jones Dan
Abstract excerpt
Diagnostic testing of pancreatic cyst fluid obtained by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has traditionally utilized elevated carcinoembryonic antigen (CEA) (≥192 ng/ml) and cytomorphologic examination to differentiate premalignant mucinous from benign pancreatic cystic lesions (PCLs). Molecular testing for KRAS/GNAS mutations has been shown to improve accuracy of detecting mucinous...
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